To help assess the risk to aquatic species where empirical data is lacking, this review presents i) a risk assessment methodology for predicting plastic litter impacts on aquatic wildlife in data poor environments, ii) a case study demonstrating this risk assessment methodology for wildlife across two heavily polluted river basins in Asia, the Mekong and Ganges River Basins; and iii) a broad review summarising common trends in litter interactions and risk to freshwater fish, aquatic birds, cetaceans and raptors. This risk analysis unites a systematic review approach with risk matrices following International Standards Organization’s risk assessment criteria, evaluating the risk of plastic entanglement and ingestion and the potential for harm to the animal.

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